… as having functional heartburn (FH). This study aimed (i) to characterize the symptoms
and functional abnormalities of patients with FH and (ii) to describe their clinical outcome. …

… a response rate beyond 50% in true functional heartburn unless if functional heartburn
overlaps with GERD. For the same reason, antireflux surgery is not going to help these patients. …

… In general, the clinical presentation of functional heartburn does not differ from the clinical
presentation of NERD or any other GERD phenotype. Heartburn severity and frequency are …

… Second, patients with non–acid-related heartburn symptoms were excluded from this study.
So our results might not be extrapolated to the subset of patients with functional heartburn in …

… [45] conducted a study comparing the physiological and clinical characteristics of a group
of 22 NERD patients (with abnormal pH test) with those of 30 FH patients (ROME II definition). …

… We aimed to compare baseline impedance levels in patients with heartburn and
pathophysiological characteristics related to … Results Demographic and clinical characteristics …

… Finally in functional heartburn (FH), heartburn occurs in the setting of normal endoscopic
findings with no correlation of symptoms with objective testing. The Rome III criteria define FH …

… This study shows that, when multivariate analysis is performed, only clinical features (ie no
esophagitis, functional disorders and normal or low BMI) are associated with PPI failure. No …

… This review highlights clinical presentation, modern diagnosis, and … The clinical presentation
of functional heartburn is similar to heartburn due to GERD, but the diagnosis of functional …

… Heartburn is a retrosternal burning sensation that is thought to result from stimulation of
acid-sensitive nerve endings in the esophageal mucosa [1,3••,4–6]. Although structures acting as …